"I eat the same as always and I weigh more" is one of the phrases heard most often in clinic during perimenopause. It's not just perception or resignation: there's a real physiological basis behind the change in body composition that happens at this stage.
The specific role of oestrogen
Beyond age, falling oestrogen encourages body fat to shift towards the abdomen, along with changes in insulin sensitivity and blood lipids. The risk of metabolic syndrome, defined by the combination of abdominal obesity, high blood pressure, impaired glucose and abnormal cholesterol, rises markedly in the years around menopause.
What the evidence says
- The incidence of metabolic syndrome rises progressively during the menopause transition, independently of age and other risk factors, according to data from longitudinal cohorts such as the SWAN study.
- Early menopause has been linked to a higher later risk of metabolic syndrome and cardiovascular disease, according to data presented in 2025 by The Menopause Society.
- Additional factors such as a history of gestational diabetes, pre-eclampsia or polycystic ovary syndrome raise individual risk even further.
It's not just about looks: it's real cardiovascular risk
Metabolic syndrome isn't only about weight or body composition: it's a direct marker of higher cardiovascular risk, precisely at the stage of life when that risk starts to climb more sharply in women. That's why it deserves the same seriousness as any other cardiovascular risk factor, not just an aesthetic approach.
The good news
Unlike other changes in menopause, metabolic syndrome responds consistently to intervention, and the earlier it's addressed, the better the long-term outlook.
A note
This content is for informational purposes only and does not replace a medical consultation.
- Maas AHEM, Rosano G, Cifkova R, et al. (2021). Cardiovascular health after menopause transition, pregnancy disorders, and other gynaecologic conditions: a consensus document from European cardiologists, gynaecologists, and endocrinologists. European Heart Journal, 42(10), 967-984.
- Janssen I, Powell LH, Crawford S, et al. (2008). Menopause and the metabolic syndrome: the Study of Women's Health Across the Nation. Archives of Internal Medicine, 168(14), 1568-1575.
- The Menopause Society (2025). Early natural menopause linked with higher risk of metabolic syndrome. Press release, 2025 Annual Meeting.